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The Spiritborn class has a number of fun playstyles for players to explore inDiablo 4: Vessel of Hatred, and if you’re a fan of spreading poison and doing big bonk damage to every enemy on the screen, then the Centipede build path is for you.
While the Centipede route is a little slow compared to Jaguar and Eagle builds, it’s one of the easiest Spiritborn setups to use, and it can wipe the entire screen clear of enemies in seconds with DoT, burst damage, and automatic execution effects. It’s a strong playstyle to use for climbingDiablo 4’sDifficulty tiers, and you can easily switch some parts of it around for easier transitioning into the endgame.
Updated Jul 13, 2025 by Marc Santos:Spiritborn received numerous balance changes in Season of Witchcraft, and the biggest ones involve a nerf to Rod of Kepeleke and a fix for a bug that caused Viscous Shield to do more damage than intended. The seasonal patch also buffed Centipede skills to be stronger and more reliable in most cases. We’ve updated this guide to account for these balance changes, and we’ve added a section covering this season’s Witchcraft Powers mechanic.
Diablo 4 Season 7 - Spiritborn Changes
Every class inDiablo 4was affected by changes implemented during Season of Witchcraft, and the ones for Spiritborn will matter mainly in the endgame. If you’re using a Spiritborn Centipede build for leveling up a new character, you’ll be glad to know that several key parts of this build were buffed. These include:
Recommended Witchcraft Powers for Season 7
For thisDiablo 4Spiritborn build, we recommend using the following Witchcraft Powers:
Diablo 4 Spiritborn Centipede Build - Active Skills
Centipede skills feature a mix of damage-over-time and healing effects with sprinkles of burst damage and Vulnerable application. This build turns your Spiritborn into a walking biohazard zone with almostzero downtime on The Devourer and Scourge.
The Devourer
This build revolves aroundScourge and the Devourer. The former spreads Poison, while the latter executes enemies who have nothing but Poison left in their health bars.Withering Fist andStingerare here as your bread-and-butter damage tools for when Scourge and the Devourer are active, whileTouch of Deathacts as a fire-and-forget Poison nuke. UseArmored Hideto break out of CC and give yourself extra defenses.
As far as leveling order is concerned,unlock the skills first, then upgrade them as follows:
This should let you unlock your Key Passive at level 25, assuming you’ve collectedall Altars of Lilith inDiablo 4for the bonus Skill Points. Otherwise, you’ll be able to reach this point by level 35.
Diablo 4 Spiritborn Centipede Build - Passives And Spirit Hall
Unless you’re struggling to deal damage, stay alive, or maintain Vigor, we recommend investing in Passive Skills after leveling up your Active Skills and unlocking your Key Passive.Many passive bonuses aren’t as impactful early on, and they only start to truly shine once you start getting some semblance of a build together. In any case, these passives should help improve your damage, survivability, and Vigor generation.
Generate Vigor per second while moving.
Follow Through (3/3)
Basic Skills deal increased damage, and more so on their third hits.
Focal Point (1/3)
Gain bonuses based on your equipped weapon. Bonuses are doubled after casting a Focus Skill.
Apex (3/3)
Deal increased damage to Vulnerable enemies. Bonus is doubled against Elites.
Patient Guard (1/3)
Gain Block Chance passively. Gain Block Damage Reduction after standing still for 0.5s.
Gain Poison Resistance and increased Poison Resistance cap.
Nourishment (3/3)
Increase Healing received. When you Heal, your Poison damage is increased.
Ravenous (3/3)
Centipede Skills deal more damage. Bonus is doubled against Healthy targets.
Oppressive (3/3)
Centipede Skills deal more damage to Crowd Controlled enemies and gain bonus Crowd Control duration.
Resolution (1/3)
Casting an Ultimate increases your damage against Elites. Double this bonus if fighting only one enemy.
Increase your max Vigor when an Ultimate is equipped.
Supremacy (3/3)
After killing an enemy while an Ultimate is active, gain a Supremacy stack that increases your damage. When your Ultimate expires, gain 5 stacks, but lose one every second.
Prodigy’s Tempo (Key Passive)
Every third consecutive cast of the same Basic Skill increases the rank of all purchased Skills by 2 for 5 seconds. Every third consecutive cast of the same Core or Potency skill decreases the active cooldown of all Skills by 10%, plus 2% for the Skills' ranks.
Prodigy’s Tempo is the heart of this build. Keep triggering the second part of this passive to massively reduce the active cooldowns of all your Skills,including The Devourer, which starts cooling down even while the Centipede is still on the field.
Spirit Hall
Players can unlock the Spirit Hall bycompleting the Sacred Hunt quest. This is basically the class' special mechanic, and it lets playerschoose two powerful passivesbased on the four available Spirit Guardians. For this build, we’ll be using the following:
Diablo 4 Spiritborn Centipede Build - Gear, Legendary Aspects, Paragon, And Runes
Gear won’t be that important in the beginning, but as you startgetting Legendary Aspects inDiablo 4, probably by around level 30 or so, you’ll want to pick the best ones that synergize with this build. The most important Aspects for this setup are:
As for item stats, look for the following:
Occult Gems
Season 7 introduced Occult Gems, which act like regular gems but with effects related to Witchcraft Powers. For thisDiablo 4Centipede Spiritborn build, use the following:
Unique Item Options
While there are plenty of ways tofarm for Uniques inDiablo 4, players are still at the mercy of RNG. If you’re lucky enough and snag any of these following Uniques, feel free to incorporate them into the build:
Wound Drinker is a high-priority Unique item that basically gives you unlimited Vigor while mobbing when combined with Tormentor’s Aspect and Scourge.
Rune Choices
Runes have made their way back toDiablo 4, and with so many potential combos out there, picking ones that are good for this Spiritborn Centipede build can be tricky. Here are some Runewords that you can try out with this build:
Paragon
Paragon farming heralds the beginning of the endgame, and the build may not to get adjusted as you get more Paragon Boards and Glyphs online. To start, we recommendgetting as much damage as possiblefrom the first board so you may start pushing for Torment difficulty. Adjust for more survivability as necessary if you’re dying too frequently.
